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Formula
C12H13ClN4
MW
248.72
Purity
>97%
Solubility (DMSO Mg/MI)
10
Bio Chemical Notes
Pyrimethamine is used in treatment of toxoplasmosis and acute malaria. It is a folic acid antagonist that inhibits the dihydrofolate reductase of plasmodia and blocks the biosynthesis of purines and pyrimidines (inhibiting DNA synthesis). Ref: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987, 2217 - 2228.