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AMT Compounds

  1. Methyl Potassium Oxalate
  2. Dimesna (Disodium 2,2'-dithiobisethane sulfonate)
  3. (3S,4S,5S,7S)-6-methyl-2-oxa-6- azatricyclo[3.3.1.0^{3,7}]nonan-4-ol
  4. 5-bromobenzo[c][1,2,5]thiadiazole
  5. 6-chloropurine riboside
  6. Benzo[c][1,2,5]oxadiazole-5-boronic acid pinacol ester
  7. 2-(3,4-dihydro-2H-1-benzopyran-6-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
  8. tert-Butyl 2-(2-methyl-1-nitropropan-2-yl)hydrazinecarboxylate
  9. Detomidine Hydrochloride
  10. Apricitabine
  11. 2-ethoxy-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile
  12. tert-butyl 4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate
  13. tert-butyl 4-[5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine-1-carboxylate
  14. 2-methyl-1-nitroprop-1-ene
  15. 4-(3-((2-Methoxyethoxy)carbonyl)ureido)phenylboronic acid pinacol ester
Interesting Chiral Amines

  1. (S)-6-bromochroman-4-amine hydrochloride
  2. (R)-2-(3,5-difluorophenyl)pyrrolidine hydrochloride
  3. (R)-4-(1-aminoethyl)benzoic acid hydrochloride
  4. (S)-methyl 2-amino-3-(5-methylpyridin-2-yl)propanoate dihydrochloride
  5. (S)-methyl 4-(piperidin-2-yl)benzoate hydrochloride
  6. (R)-1-(4-((trifluoromethyl)thio)phenyl)ethanamine hydrochloride
  7. (5R)-5-amino-5-phenylpentanoic acid hydrochloride
  8. (R)-1-(4-fluorophenyl)but-3-en-1-amine hydrochloride
  9. (2S)-2-amino-3-[4-(trifluoromethoxy)phenyl]propanoic acid hydrochloride
  10. methyl 3-((1R)-1-amino-2-hydroxyethyl)benzoate hydrochloride
  11. (1S)-1-(furan-2-yl)ethan-1-amine hydrochloride
  12. (R)-cyclopropyl(3-methoxyphenyl)methanamine hydrochloride
  13. (1S)-1-(thiophen-2-yl)ethan-1-amine hydrochloride
  14. (R)-6-(trifluoromethoxy)chroman-4-amine hydrochloride
  15. 4-((2S)pyrrolidin-2-yl)-2,2-difluorobenzo[d]1,3-dioxolane hcl
Selected New Building Blocks

  1. 3-Nitro-1H-pyrazole-4-carboxylic acid
  2. Cyano-(2-nitro-5-trifluoromethyl-phenyl)acetic acid benzyl ester
  3. 6-Piperazin-1-ylnicotinic acid
  4. 4-Fluoro-DL-glutamic acid
  5. (3S)-1-[(3-Chloro-2-methylbenzene)sulfonyl]-N-cyclohexylpiperidine-3-carboxamide
  6. 1-Bromo-3,3,4,4,5,5,6,6,6-nonafluorohexane
  7. Benzyl 2-(3-(((tert-butoxycarbonyl)amino)methyl)oxetan-3-yl)acetate
  8. 4-Borono-3,5-difluorobenzoic acid
  9. 2,2-dioxo-2λ⁶-thia-9-bismatricyclo[8.4.0.0³,⁸]tetradeca-1(10),3(8),4,6,11,13-hexaen-9-yl 4-methylbenzene-1-sulfonate
  10. 5-(difluoromethyl)pyridine-3-sulfonyl chloride
  11. rac-(1R,2S)-2-phenylcyclopropane-1-sulfonyl chloride
  12. 3-acetamido-4-fluorobenzene-1-sulfonyl chloride
  13. ethyl 4-chloro-2-(morpholin-4-yl)pyrimidine-5-carboxylate
  14. 4-chloro-2-[(Z)-(2-chlorophenyl)(hydroxyimino)methyl]aniline
  15. 1-(2-aminophenyl)propan-2-ol
Selected New Fragments & Screening

  1. rac-tert-butyl (R)-(1-methyl-1H-imidazol-2-yl)[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl carbonate
  2. 4-bromo-2,6-bis(propan-2-yl)phenol
  3. spiro[indene-1,4'-piperidine]
  4. 4-(methoxycarbonyl)-1-methylpyridin-1-ium iodide
  5. 5-amino-1-[(2-chlorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide
  6. 2-acetyl-4-chlorophenyl 4-methylbenzoate
  7. 6-chloro-2-(2-methylphenyl)-4H-chromen-4-one
  8. rac-tert-butyl N-[(1R)-1-carbamoyl-2-phenylethyl]carbamate
  9. 6-chloro-2-(3-methylphenyl)-4H-chromen-4-one
  10. 2-acetyl-4-chlorophenyl 2-methylbenzoate
  11. 2-acetyl-4-chlorophenyl benzoate
  12. 6-chloro-2-(3-methoxyphenyl)-4H-chromen-4-one
  13. rac-tert-butyl N-[(1R)-1-cyano-2-phenylethyl]carbamate
  14. 2-acetyl-4-bromophenyl 4-methylbenzoate
  15. 1,1,3,3-tetraethoxy-2-methylpropane

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FRAGMENTS & SCREENING

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from the blog
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03Aug

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02Jun

Welcome Dr Graham Wynne

Key Organics are delighted to welcome Dr Graham Wynne as Medicinal Chemistry Consultant.