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Formula
C22H20N2O4
MW
376.42
Purity
>97%
Solubility (DMSO Mg/MI)
20
Storage (Powder)
3 Years -20?C
Storage (Solvent)
1 Year -80?C
Indication
Leukemia
Mode Of Action
inhibitor
Drug Status
Approved
Target Name
DNA topoisomerase I (TOP1)
Research Area
CANCER
Research Area Sub Group
Anticancer
Pharmacology
ENZYMES
Pharmacology Area Sub Group
Isomerase
Bio Chemical Notes
An analogue of Camptothecin (KS-5235), which is effective against murine leukemia. It acts as an inhibitor of Topoisomerase I. Ref: Cancer Treatment Reports 1987; 71 (4); 341-348.