Custom Enquiry
We aim to give you a response from a qualified scientist within a hour.
Review The SDS Document
DOWNLOADProduct Details
Formula
C14H8N2O
MW
220.23
Purity
>97%
Solubility (DMSO Mg/MI)
40
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
N/A
Mode Of Action
inhibitor
Target Name
Stress-activated protein kinase JNK1 (JNK1)/Stress-activated protein kinase JNK2 (JNK2)/Stress-activated protein kinase JNK3 (JNK3)
Research Area
OTHER
Pharmacology
ENZYMES
Pharmacology Area Sub Group
Kinase
Bio Chemical Notes
SP600125 is a broad-spectrum JNK inhibitor for JNK1, JNK2 and JNK3 with IC50 of 40 nM, 40 nM and 90 nM, respectively; 10-fold greater selectivity against MKK4, 25-fold greater selectivity against MKK3, MKK6, PKB, and PKCα, and 100-fold selectivity against ERK2, p38, Chk1, EGFR etc.