Review The SDS Document
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Formula
C26H31ClN2O8S
MW
567.06
Purity
>97%
Solubility (DMSO Mg/MI)
82
Bio Chemical Notes
Acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation and preventing calcium-dependent myocyte contraction and vasoconstriction. Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity. Ref: Drugs. 1991; 41 (3), 478-505.