Review The SDS Document
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Formula
C22H22ClKN6O
MW
461.01
Purity
>97%
Solubility (DMSO Mg/MI)
90
Bio Chemical Notes
Losartan and its longer acting metabolite, E-3174, lower blood pressure by antagonizing the renin-angiotensin-aldosterone system (RAAS). They both are specific and selective type-1 angiotensin II receptor (AT1) antagonists. Ref: The Journal of Biological Chemistry. 1994; 269, 16533-16536.