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Formula
C20H19N5Na2O6
MW
471.38
Purity
>97%
Solubility (DMSO Mg/MI)
INSOLUBLE
Bio Chemical Notes
A chemotherapy drug used in combination with cisplatin for the treatment of malignant pleural mesothelioma and non-small-cell lung cancer. It is an anitfoliate which acts by inhibiting the enzymes thymidylate synthase, dihydrofolate reductase and glycinamide ribonucletide formyltrasferase. Ref: Clinical Lung Cancer 2002; 5 (S2); S51-55.