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Product Details
Formula
C30H29ClN6O3
MW
557.05
Purity
>95%
Solubility (DMSO Mg/MI)
5
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
Breast Cancer
Mode Of Action
inhibitor
Drug Status
Approved
Target Name
Epidermal growth factor receptor (EGFR)
Research Area
CANCER
Research Area Sub Group
Anticancer
Pharmacology
ENZYME-LINKED RECEPTORS
Pharmacology Area Sub Group
Kinase
Bio Chemical Notes
Neratinib (HKI-272) is a highly selective HER2 and EGFR inhibitor with IC50 of 59 nM and 92 nM in cell-free assays; weakly inhibits KDR and Src, no significant inhibition to Akt, CDK1/2/4, IKK-2, MK-2, PDK1, c-Raf and c-Met.