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Product Details
Formula
C30H22F2N6O3
MW
552.54
Purity
>95%
Solubility (DMSO Mg/MI)
95
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
Solid Tumors, Advanced Cancer, ColoRectal Cancer and Metastatic Cancer
Mode Of Action
inhibitor
Drug Status
Phase 1
Target Name
Tyrosine kinase receptor (ALK)
Research Area
CANCER
Research Area Sub Group
Anticancer
Pharmacology
ENZYME-LINKED RECEPTORS
Pharmacology Area Sub Group
Kinase
Bio Chemical Notes
LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (Ki) of 2 nM, a pharmacodynamic residence time (Koff) of 0.00132 min(-1) and t1/2 of 525 min.