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Product Details
Formula
C29H27F3N6O
MW
532.57
Purity
>98%
Solubility (DMSO Mg/MI)
30
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
Leukemia
Mode Of Action
inhibitor
Drug Status
Approved
Target Name
Tyrosine-protein kinase ABL1
Research Area
CANCER
Research Area Sub Group
Anticancer
Pharmacology
ENZYME-LINKED RECEPTORS
Pharmacology Area Sub Group
Kinase
Bio Chemical Notes
Ponatinib (AP24534) is a novel, potent multi-target inhibitor of Abl, PDGFRα, VEGFR2, FGFR1 and Src with IC50 of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM and 5.4 nM in cell-free assays, respectively.