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Product Details
Formula
C26H23FIN5O4
MW
615.4
Purity
>99%
Solubility (DMSO Mg/MI)
20
Storage (Powder)
3 Years -20°C
Storage (Solvent)
1 Year -80°C
Indication
Lung Cancer, Melanoma and Thyroid Cancer
Mode Of Action
inhibitor
Drug Status
Approved
Target Name
Mitogen-activated protein kinase kinase 1 (MEK1)/Mitogen-activated protein kinase kinase 2 (MEK2)
Research Area
CANCER
Research Area Sub Group
Anticancer
Pharmacology
ENZYMES
Pharmacology Area Sub Group
Kinase
Bio Chemical Notes
Trametinib (GSK1120212) is a highly specific and potent MEK1/2 inhibitor with IC50 of 0.92 nM/1.8 nM in cell-free assays, no inhibition of the kinase activities of c-Raf, B-Raf, ERK1/2.