Fragment-based lead discovery (FBLD) is now broadly practised throughout the drug research community and a number of compounds that evolved from fragments have now entered clinical trials. FBLD involves the screening of small libraries of fragments that typically obey the Rule of Three (Ro3). Pre-requisites for fragment screening are a diverse library of compounds with good aqueous solubility.
The BIONET Premium Fragment Library consists of 931 fragments with experimentally assured aqueous solubility, high purity (≥95%), excellent diversity (Diversity Coefficient = 0.78) and were selected based on Ro3 criteria, chemical tractability and potential for fragment evolution.
Click here to download the flyer for further information on the library itself.
Click here to download a zipped SDF of the complete library.
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