90% OF PRODUCTS IN STOCK
ASSURED QUALITY GUARANTEED
SAME DAY DESPATCH
KG PRICING ON REQUEST
Stable Isotope Labelled Building Blocks/Intermediates and Custom Synthesis
Stable labels (mainly 13C and Deuterium) are widely used in the Pharmaceutical Industry primarily for use in DMPK studies. However, in recent years the industry has been investigating the advantages of deuterium in drug molecules with compounds now FDA approved, for example Deutetrabenazine and Deucravacitinib. There are many more in late stage development.
The potential advantages of deuterated compounds are:
- Improved oral bioavailability
- Increased half-life
- Improved metabolic profile
- Wider IP cover
In the Agrochemical Industry, stable isotopes like 13C and 15N are used for tracing agrochemical fate, tracking the compounds’ persistence and environmental impact as well as being used in mechanistic and kinetic experiments.
At Key Organics, as well as having a collection of over 10,000 stable labelled building blocks, we have extensive experience in providing stable labels on a custom synthesis basis to our clients.
Stable labelled intermediates also have a variety of applications beyond the pharmaceutical and agricultural industries.
Here are some key benefits:
- Environmental Science: They are used in tracing the movement of pollutants in the environment. By tracking stable isotopes, scientists can understand the sources and pathways of contaminants in soil, water, and air.
- Food and Nutrition: In food science, stable labelled intermediates help in studying metabolic processes and nutrient absorption. This can lead to better understanding of dietary impacts on health and the development of fortified foods.
- Forensic Science: These intermediates are valuable in forensic investigations for tracing the origins of substances and understanding chemical compositions in crime scene analysis.
- Material Science: In material science, they are used to study the properties and behaviors of new materials. This can lead to the development of more durable and efficient materials for various applications.
- Biological Research: Stable labelled intermediates are crucial in studying biochemical pathways and mechanisms within living organisms. This can enhance our understanding of diseases and lead to new therapeutic approaches.
These applications highlight the versatility and importance of stable labelled intermediates in advancing scientific research and technology across multiple fields.
References:
Elmore et al: Bioorganic & Medicinal Chemistry Letters, Volume 25, Issue 2, 15 January 2015, Pages 167-171
Pirali et al: Nature Reviews Drug Discovery, volume 22, pages 562–584 (2023)
Innovations in Agrochemical and Pharma Intermediates – Reachem
Benefits of our Collections:
Re-supply and Bulk supply for follow up research.
A large proportion of our collection is available in bulk quantities; this means we can ensure a very high level of re-supply to help your project succeed.
And if you want to explore analogues or some initial Process Development Chemistry, our specialist team would love to help.
Advantages of purchasing directly from BIONET:
- Ease of purchasing directly through our online shop, by phone, or via e-mail
- Usually dispatched from stock same day
- We maintain good stock levels
- Dedicated customer relations department
Database Download:
To download all the latest BIONET databases, in SD and MS Excel file formats
