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DNA encoded Chemical Libraries
The use of DNA-encoded chemical libraries (DELs) is an ever expanding tool in early phase drug discovery. Globally, researchers have been expanding the range of compatible chemistries to further populate chemical space using this technique. 1,2
Key Organics has a diverse building block collection of over 220,000 compounds and can expand this collection with our trusted partners, using our Compound Management Service and our experience of curating and delivering fragment libraries in various formats we can supply collections of compounds to feed into your DEL project.
All the common functionalities for DEL are covered and we can deliver bi and tri functional compounds, filtered on calculated physical properties (Mwt, ClogP etc) as well as on lead time, cost and unacceptable functionality.
Bifunctional DEL-compatible scaffolds
- Aldehyde - Aryl halide
- Aldehyde - Azide
- Aldehyde - Carboxylic acid
- Aldehyde - Ester
- Aldehyde - NBOC-amine
- Aldehyde - Nitro
- Aldehyde - Sulfonyl halide
- Amine - Aryl halide
- Amine - Azide
- Amine - Ester
- Amine - N-benzyl amine
- Amine - NBOC - amine
- Amine - NCbz - amine
- Amine - NFMOC - amine
- Aryl halide - Aryl halide
- Aryl halide - Terminal Alkyne
- Azide - Aryl halide
- Azide - Sulfonyl halide
- Carboxylic acid - Aryl halide
- Carboxylic acid - Azide
- Carboxylic acid - Ester
- Carboxylic acid - Isothiocyanate
- Carboxylic acid - Nitro
- Carboxylic acid - Terminal Alkyne
- Ester - Isocyanate
- Ester - Sulfonyl halide
- Functional boronates
- NBOC - Amino acid
- NCbz - Amino acid
- NFMOC - Amino acid
Trifunctional DEL-compatible scaffolds
- Aldehyde - NBOC amine - Ester
- Amine - Aryl halide - Aryl halide
- Amine - Aryl halide - Nitro
- Amine - NBOC amine - Aryl halide
- Amine - NBOC amine - Ester
- Aryl halide - Aryl halide - Aryl halide
- Aryl halide - NBOC - amino acid
- Aryl halide - NFMOC - amino acid
- Carboxylic acid - Aldehyde - Aryl halide
- Carboxylic acid - Aldehyde - Nitro
- Carboxylic acid - Aryl halide - Aryl halide
- Carboxylic acid - Aryl halide - Ester
- Carboxylic acid - Aryl halide - Nitro
- Carboxylic acid - Ester - Nitro
- Ester - NBOC - Amino acid
- Ester - NFMOC - Amino acid
- NBOC - NFMOC - Diamino acid
- NBOC - NCbz - diamino acid
- Nitro - NBOC - amino acid
- Nitro - NFMOC - amino acid
- Terminal Alkyne - NBOC - amino acid
- Terminal Alkyne - NFMOC - Amino acid
References:
- Hupp et al: Bioorganic & Medicinal Chemistry Letters Volume 51, 1 November 2021, 128339
- Martin et al: Nature Communications Chemistry volume 3, Article number: 127 (2020)
Benefits of our Collections:
Re-supply and Bulk supply for follow up research.
A large proportion of our collection is available in bulk quantities; this means we can ensure a very high level of re-supply to help your project succeed.
And if you want to explore analogues or some initial Process Development Chemistry, our specialist team would love to help.
Advantages of purchasing directly from BIONET:
- Ease of purchasing directly through our online shop, by phone, or via e-mail
- Usually dispatched from stock same day
- We maintain good stock levels
- Dedicated customer relations department
Database Download:
To download all the latest BIONET databases, in SD and MS Excel file formats
